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KMID : 1002120080050010033
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Journal of Korean Sleep Research Society
2008 Volume.5 No. 1 p.33 ~ p.38
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Recent Update of Restless Legs Syndrome
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Kim Kwang-Ki
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Abstract
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Restless legs syndrome (RLS) is a very frequent neurological disorder characterised by sensory and motor symptoms. The diagnosis of RLS basically relies on the presence of 4 clinical criteria defined by the International RLS Study Group. So RLS is can be composed of various pathogenetic mechanisms. This review focuses on the recent developments in pathophysiology of RLS, with particular emphasis on the background of recent developments in genetics, neuroimaging, and animal studies. Neuroanatomical, neurophysiological, neuropharmacological, and neurogenetic findings have to be merged to reveal the secrets of restless legs syndrome.
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KEYWORD
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Restless legs syndrome, Pathophysiology
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